Research

Research

Check out the research behind our programs and see which current studies are open for recruitment.

Participate In Our Research

Would you like to participate in our research? We conduct our clinical trials through the Virtual Clinic to evaluate internet-based education and treatment programs for anxiety and depression. To find out more about eligibility criteria and how you can get involved, please visit the Virtual Clinic website. You can make a valuable contribution to mental health research simply by sharing your experience, time and knowledge with our researchers.
Participate Today

Evidence For Our Programs

Before our depression and anxiety treatment programs are released through THIS WAY UP, they are rigorously tested by our research unit, Virtual Clinic. We have treated over 1,400 patients in Virtual Clinic, using versions of the depression, panic, social phobia, GAD, and transdiagnostic programs, and have found that the programs significantly reduce anxiety and depression.

THIS WAY UP is the platform through which we make the research-based programs and our free, evidence-based programs available. As of February 2021, we have had more than 22,616 clinicians and more than 103,775 patients enrolled in THIS WAY UP.

The degree of benefit gained from THIS WAY UP depends on the level to which people immerse themselves in the programs, and on how much they practice what they learn in each lesson. Three out of four people complete all the lessons, and three out of four who complete are no longer troubled by their emotional disorder. Nine out of ten say they are satisfied. Internationally, our programs are among the strongest presently available for these conditions.

Published Research Papers

Please find a listing below of the research papers that have been published in peer reviewed journals. For the complete list, please visit our CRUfAD website.

Randomised controlled trial of internet‐delivered cognitive behaviour therapy for clinical depression and/or anxiety in cancer survivors (iCanADAPT Early). Murphy, M. J., Newby, J. M., Butow, P., Loughnan, S. A., Joubert, A. E., Kirsten, L., … & Andrews, G. Psycho‐Oncology. 2019.

Available at: www.onlinelibrary.wiley.com/doi/abs/10.1002/pon.5267

Adherence as a determinant of effectiveness of internet cognitive behavioural therapy for anxiety and depressive disorders. Hilvert-Bruce Z, Rossouw PJ, Wong N, Sunderland M, Andrews G. Behaviour Research and Therapy. 2012, 50(7-8): 463-468.

Available at: www.ncbi.nlm.nih.gov/pubmed/22659155

Investigating trajectories of change in psychological distress amongst patients with depression and generalised anxiety disorder treated with internet cognitive behavioural therapy. Sunderland M, Wong N, Hilvert-Bruce Z, Andrews G Behaviour Research and Therapy. 2012, 50(6): 374-380.

Available at: www.ncbi.nlm.nih.gov/pubmed/22498311

Is Internet treatment ready for prime time? Andrews G, Titov N. MJA 2010; 192 (11): S45-S47.

Available at: www.ncbi.nlm.nih.gov/pubmed/20528709

Characteristics of adults with anxiety or depression treated at an Internet clinic: Comparison with a national survey and an outpatient clinic. Titov N, Andrews G, Kemp A, Robinson E. PLoS ONE 2010, 5(5): e10885. doi:10.1371/journal.pone.0010885.

Available at: www.journals.plos.org/plosone/article?id=10.1371/journal.pone.0010885

Hit and Miss: Innovation and dissemination of evidence based psychological treatments. Andrews G, Titov N. Behaviour Research and Therapy 2009; 47:974-979.

Available at: www.ncbi.nlm.nih.gov/pubmed/19625014

A clinical audit of changes in suicide ideas with internet treatment for depression. Watts S, Newby J, Mewton L, Andrews G. British Medical Journal Open. 2012 2: e001558.

Available at: bmjopen.bmj.com/content/2/5/e001558

Internet treatment for depression: A randomized controlled trial comparing clinician vs. technician assistance. Titov N, Andrews G, Davies M, McIntyre K, Robinson E, Solley K. PLoS ONE 2010, 5(6): e10939. doi:10.1371/journal.pone.0010939.

Available at: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010939

Clinician-assisted Internet-based treatment is effective for depression: A randomized controlled trial. Perini S, Titov N, Andrews G. Australian and New Zealand Journal of Psychiatry. (2009). 43(6): 571-578.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/19440890

The Climate Sadness program: an open trial of Internet-based treatment for depression. Perini S, Titov N, Andrews G. Electronic Journal of Applied Psychology 2008; 4(2).

Available at: http://sensoria.swinburne.edu.au/index.php/sensoria/article/view/135

The effectiveness of internet-delivered cognitive behavioural therapy for health anxiety in routine care. Newby, J. M., Haskelberg, H., Hobbs, M. J., Mahoney, A. E., Mason, E., & Andrews, G. Journal of Affective Disorders. 2019.

Available at: www.sciencedirect.com/science/article/abs/pii/S0165032719316489

The impact of internet-delivered cognitive behavioural therapy for health anxiety on cyberchondria. Newby, J. M., & McElroy, E. Journal of Anxiety Disorders, 102150. 2019.

Available at: www.sciencedirect.com/science/article/pii/S088761851930218X

Transdiagnostic Internet treatment for anxiety disorders: A randomized controlled trial. Titov N, Andrews G, Johnston L, Robinson E, Spence J. Behaviour Research and Therapy 2010. doi:10.1016/j.brat.2010.05.014

Available at: http://www.ncbi.nlm.nih.gov/pubmed/19440890

Effectiveness of transdiagnostic internet cognitive behavioural treatment for mixed anxiety and depression in primary care. Newby JM, Mewton L, Williams AD, Andrews G. Journal of Affective Disorders. 2014, 165: 45-52.

Available at: http://www.sciencedirect.com/science/article/pii/S0165032714002316

Internet cognitive behavioural therapy for mixed anxiety and depression: a randomized controlled trial and evidence of effectiveness in primary care. Newby JM, Mackenzie A, Williams AD, Mcintyre K, Watts S, Wong N, Andrews G. 2013, 43(12): 2635-2648.

Available at: http://www.sciencedirect.com.simsrad.net.ocs.mq.edu.au/science/article/pii/0887618594900019

The effectiveness of internet cognitive behavioural therapy for generalised anxiety disorder in clinical practice. Mewton L, Wong N, Andrews G Depression and Anxiety. 2012, 29(10): 843-849.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/22949296

Internet treatment for generalized anxiety disorder: A randomized controlled trial comparing clinician vs. technician assistance. Robinson E, Titov N, Andrews G, McIntyre K, Schwencke G, Solley K. PLoS ONE 2010, 5(6): e10942. doi:10.1371/journal.pone.0010942.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/20532167

Clinician-assisted internet treatment is effective for generalized anxiety disorder: randomized controlled trial. Titov N, Andrews G, Robinson E, Schwencke G, Johnston L, Solley K, Choi I. Australian and New Zealand Journal of Psychiatry 2009, 43:10, 905-912.

Available at: http://anp.sagepub.com/content/43/10/905

Allen AR, Newby JM, Mackenzie A, Smith J, Boulton M, Loughnan SA, Andrews G. Internet cognitive behavioural treatment for panic disorder: a randomised controlled trial and evidence of effectiveness in primary care. British Journal of Psychiatry Open. 2016; 2: 154-162.

Available at:http://bjpo.rcpsych.org/content/2/2/154

Clinician-assisted Internet-based treatment is effective for panic: A randomized controlled trial. Wims E, Titov N, Andrews G, Choi I. Australian and New Zealand Journal of Psychiatry 2010; 44:599-607.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/20560847

The Climate Panic program: an open trial of Internet-based treatment for panic disorder. Wims E, Titov N, Andrews G. Electronic Journal of Applied Psychology 2008; 4(2).

Available at: http://ojs.lib.swin.edu.au/index.php/ejap/article/view/134

Internet treatment for social phobia reduces comorbidity. Titov N, Gibson M, Andrews G, McEvoy P. Australian and New Zealand Journal of Psychiatry 2009; 43:754-9.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/19629797

An RCT comparing effect of two types of support on severity of symptoms for people completing Internet-based cognitive behaviour therapy for social phobia. Titov N, Andrews G, Schwencke G, Solley K, Johnston L, Robinson E. Australian and New Zealand Journal of Psychiatry 2009; 43:10,920 — 926.

Available at: http://anp.sagepub.com/content/43/10/920

Randomized controlled trial of web-based treatment of social phobia without clinician guidance. Titov N, Andrews G, Choi I, Schwencke G, Johnston L. Australian and New Zealand Journal of Psychiatry 2009; 43:913 — 919.

Available at: http://anp.sagepub.com/content/43/10/913

The Shyness Program: Longer Term Benefits, Cost-Effectiveness, and Acceptability. Titov, N., G. Andrews, et al. Australian & New Zealand Journal of Psychiatry 2009; 43: 36-44.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/19085526

Shyness 5: The clinical effectiveness of Internet-based clinician-assisted treatment of social phobia. Aydos L R, Titov N, Andrews G. Australasian Psychiatry 2009; 17:488-492.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/20001373

Shyness 3: An RCT of guided vs unguided internet based CBT for social phobia. Titov N, Andrews G, Choi I, Schwencke G, Mahoney A. Australian & New Zealand Journal of Psychiatry 2008; 42:1030-1040.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/19016091

Shyness 2: Treating social phobia online: replication and extension. Titov N, Andrews G, Schwencke G. Australian and New Zealand Journal of Psychiatry 2008; 42:595-605.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/18612863

Shyness 1: Distance treatment for social over the Internet. A randomized controlled trial. Titov N, Andrews G, Schwencke G, Drobny J, Einstein D. Australian & New Zealand Journal of Psychiatry 2008; 42:585-594.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/18612862

 

Characteristics of adults with anxiety or depression treated at an Internet clinic: Comparison with a national survey and an outpatient clinic. Titov N, Andrews G, Kemp A, Robinson E. PLoS ONE 2010, 5(5): e10885. doi:10.1371/journal.pone.0010885.

Available at: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010885

Grisham JR, Williams AD. Responding to intrusions in obsessive-compulsive disorder: The roles of neuropsychological functioning and beliefs about thoughts. Journal of Behavior Therapy and Experimental Psychiatry. 2013; 44: 343-350.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/23501288

Mahoney A, Andrews G. Internet-based cognitive behaviour therapy for obsessive compulsive dsorder. In: Crowe E, O’Dell AR, editors. Obessive-Compulsive Disorder: Symptoms, Prevalence and Psychological Treatments: Nova; 2014.

Mahoney AEJ, Mackenzie A, Williams AD, Smith J, Andrews G. Internet cognitive behavioural treatment for obsessive compulsive disorder: A randomised controlled trial. Behaviour Research and Therapy. 2014; 63: 99-106.

Available at: http://www.ncbi.nlm.nih.gov/pubmed/25461784

Derek Z Lim, BMed, MD, Jill M Newby, PhD, Tania Gardner, PhD, Hila Haskelberg, PhD, Regina Schultz, PhD, Steven G Faux, MBBS, FRACGP, FAFRM(RACP), FFPMANZCA, Christine T Shiner, PhD, Evaluating Real-World Adherence and Effectiveness of the “Reboot Online” Program for the Management of Chronic Pain in Routine Care, Pain Medicine, 2021;, pnaa458.

Available at: https://doi.org/10.1093/pm/pnaa458

Schultz R, Newby JM, Gardner T, Shiner CT, Andrews G, Faux SG. Pilot Trial of the Reboot Online Program: An Internet-Delivered, Multidisciplinary Pain Management Program for Chronic Pain. Pain Research and Management. 2018;1.

Available at: https://doi.org/10.1155/2018/9634727

Smith J, Faux SG, Gardner T, Hobbs MJ, ames MA, JJoubert AE, Kladnitski N, Newby JM, Schultz R, Shiner CT, Andrews G. Reboot Online: A Randomized Controlled Trial Comparing an Online Multidisciplinary Pain Management Program with Usual Care for Chronic Pain. Pain Medicine. 2019; 20(12): 2385-2396.

Available at: https://doi.org/10.1093/pm/pnz208

Kladnitski, N., Smith, J., Uppal, S., James, M., Allen, A., Andrews, G., & Newby, J.M. (2020). Transdiagnostic Internet-Delivered CBT and Mindfulness-Based Treatment for Depression and Anxiety: a Randomised Controlled Trial. Internet Interventions, 20, 1-14

Available at: https://www.sciencedirect.com/science/article/pii/S2214782919301289 

Kladnitski, N., Smith, J., Allen, A., Andrews, G., & Newby, J.M. (2018). Online Mindfulness-Enhanced Cognitive Behavioural Therapy for Anxiety and Depression: Outcomes of a Pilot Trial. Internet Interventions, 13, 41-50.

Available at: https://www.sciencedirect.com/science/article/pii/S2214782918300071